Depression is due to the changes in serotonin level, serotonin a brain hormone which regulates the mood. People who suffer from depression experience intense feelings of hopelessness, melancholy, and sadness for lingering periods of time and in time this condition can lead to a range of symptoms which have very terrible effects.  Women who are approaching the menopausal stage are at a higher risk for depression, and two current studies show strong evidence that hormonal changes may be at least partially to blame. Both studies followed women through menopausal transition called perimenopause. It is also observed that part of the symptom of a hormonal changes which is menopause, is that women are likely to develop depression.